Produção científica

Condrócito - Ciclo Circadiano

• The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity.
  J Clin Invest. 2016 Jan;126(1):365-76. doi: 10.1172/JCI82755. Epub 2015 Dec 14.
  https://pubmed.ncbi.nlm.nih.gov/26657859/
• The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?
  Rheumatology (Oxford). 2021 Jul 1;60(7):3048-3057. doi: 10.1093/rheumatology/keab197
  https://pubmed.ncbi.nlm.nih.gov/33630038/
• Drugging the circadian clock feedback cycle to ameliorate cartilage degeneration.
  FEBS J. 2022 Nov;289(21):6643-6658. doi: 10.1111/febs.16601. Epub 2022 Sep 1.
  https://pubmed.ncbi.nlm.nih.gov/35997219/
• Cartilage-specific deficiency of clock gene Bmal1 accelerated articular cartilage degeneration in osteoarthritis by up-regulation of mTORC1 signaling.
  Int Immunopharmacol . 2023 Feb;115:109692. doi: 10.1016/j.intimp.2023.109692. Epub 2023 Jan 9.
  https://pubmed.ncbi.nlm.nih.gov/36628892/